Omecamtiv mecarbil ( CK-1827452 )

Catalog No. M16353 CAS No. 873697-71-3

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Product Name

Omecamtiv mecarbil
Note

Research use only, not for human use.
Brief Description

Omecamtiv mecarbil (CK-1827452) is the first potent cardiac myosin activator that can specifically activate the cardiac myosin S1 domain but not other muscle myosins.
Description

Omecamtiv mecarbil (CK-1827452) is the first potent cardiac myosin activator that can specifically activate the cardiac myosin S1 domain but not other muscle myosins. In clinical trials, omecamtiv mecarbil has been considered as a promising therapeutic approach to treat systolic heart failure1.
Synonyms

CK-1827452
Pathway

Endocrinology/Hormones
Target

ATPase
Recptor

ATPase
Research Area

Cardiovascular Disease
Indication

——

CAS Number

873697-71-3
Formula Weight

401.43
Molecular Formula

C20H24FN5O3
Purity

>98%(HPLC)
Solubility

Ethanol: 6 mg/mL (14.94 mM); DMSO: 80 mg/mL (199.28 mM)
SMILES

O=C(N1CCN(CC2=CC=CC(NC(NC3=CC=C(C)N=C3)=O)=C2F)CC1)OC
Chemical Name

methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate

1.Anderson RL, et al. Mol Bio Cell, 2005, 16.

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